Assoc Prof Gavin Stewart Dawe

 

Gavin Stewart Dawe
Associate Professor and Head of Department, Department of Pharmacology,
Director, Neuroscience and Metabolic Phenotyping Core,
National University of Singapore
16 Medical Drive, #04-01Y, Singapore 117600
Tel: 6516 8864
Email: gavindawe@nus.edu.sg
Website: https://nus.edu.sg/lsi/principal-investigators-3/assoc-prof-gavin-stewart-dawe/

Major Research Interests

  • Neurobiology of amyloid precursor protein (APP)
  • Neuropeptides and stapled peptides
  • Neuropsychopharmacology of antipsychotics, anxiolytics, and antidepressants

    • Recent Publications

    1. Cnops V, Iyer VR, Parathy N, Wong P, Dawe GS. Test, rinse, repeat: A review of carryover effects in rodent behavioral assays. Neurosci Biobehav Rev. 2022 Apr;135:104560.
    2. Wong WLE, Dawe GS, Young AH. The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review. Neurosci Biobehav Rev. 2021 Dec;131:429-450.
    3. Suresh J, Khor IW, Kaur P, Heng HL, Torta F, Dawe GS, Tai ES, Tolwinski NS. Shared signaling pathways in Alzheimer’s and metabolic disease may point to new treatment approaches. FEBS J. 2021 Jun;288(12):3855-3873. doi: 10.1111/febs.15540.
    4. Teh DBL, Bansal A, Chai C, Toh TB, Tucker RAJ, Gammad GGL, Yeo Y, Lei Z, Zheng X, Yang F, Ho JS, Bolem N, Wu BC, Gnanasammandhan MK, Hooi L, Dawe GS, Libedinsky C, Ong WY, Halliwell B, Chow EK, Lim KL, Zhang Y, Kennedy BK. A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Adv Mater. 2020 Jul;32(29):e2001459.
    5. Marwari S, Poulsen A, Shih N, Lakshminarayanan R, Kini RM, Johannes CW, Dymock BW, Dawe GS. Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats. Br J Pharmacol. 2019 Oct;176(20):3899-3923.
    6. Marwari S, Dawe GS. Effects of haloperidol on cognitive function and behavioural flexibility in the IntelliCage social home cage environment. Behav Brain Res. 2019 Oct 3;371:111976.
    7. Basil AH, Gross M, Rajkumar R, Kirby M, Pinhasov A, Dawe GS. Social defeat-induced Cingulate gyrus immediate-early gene expression and anxiolytic-like effect depend upon social rank. Brain Res Bull. 2018 Oct;143:97-105.
    8. Rajkumar R, Dawe GS. OBscure but not OBsolete: Perturbations of the frontal cortex in common between rodent olfactory bulbectomy model and major depression. J Chem Neuroanat. 2018 Sep;91:63-100.
    9. Marwari S, Dawe GS. (R)-fluoxetine enhances cognitive flexibility and hippocampal cell proliferation in mice. J Psychopharmacol. 2018 Apr;32(4):441-457.
    10. Liu C, Zhang CW, Zhou Y, Wong WQ, Lee LC, Ong WY, Yoon SO, Hong W, Fu XY, Soong TW, Koo EH, Stanton LW, Lim KL, Xiao ZC, Dawe GS. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018 Mar;25(4):661-676.
    11. Shalini SM, Ho CF, Ng YK, Tong JX, Ong ES, Herr DR, Dawe GS, Ong WY. Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory. Mol Neurobiol. 2018 Feb;55(2):1537-1550.
    12. Li S, Wang X, Ma QH, Yang WL, Zhang XG, Dawe GS, Xiao ZC. Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway. Sci Rep. 2016 Dec 23;6:39320.
    13. Lim EP, Dawe GS, Jay TM. Activation of beta- and alpha-2-adrenoceptors in the basolateral amygdala has opposing effects on hippocampal-prefrontal long-term potentiation. Neurobiol Learn Mem. 2017;137:163-170.
    14. Kumar JR, Rajkumar R, Jayakody T, Marwari S, Hong JM, Ma S, Gundlach AL, Lai MKP, Dawe GS. Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders. Br J Pharmacol. 2017 May;174(10):1061-1076.
    15. Rajkumar R, Kumar JR, Dawe GS. Priming locus coeruleus noradrenergic modulation of medial perforant path-dentate gyrus synaptic plasticity. Neurobiol Learn Mem. 2017 Feb;138:215-225.
    16. Kumar JR, Rajkumar R, Lee LC, Dawe GS. Nucleus incertus contributes to an anxiogenic effect of buspirone in rats: Involvement of 5-HT1A receptors. Neuropharmacology. 2016 Nov;110(Pt A):1-14.
    17. Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS. Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity. Peptides. 2016 Oct;84:44-57.
    18. Korpi ER, den Hollander B, Farooq U, Vashchinkina E, Rajkumar R, Nutt DJ, Hyytiä P, Dawe GS. Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. Pharmacol Rev. 2015 Oct;67(4):872-1004.