Assoc Prof S Thameem DHEEN

 

S Thameem Dheen
(PhD; M Phil; MSc; BSc)
Head, Department of Anatomy, NUS Medicine
Member, LSI Neurobiology Programme
Member, NUS Medicine Healthy Ageing Translational Research Program
National University of Singapore
4 Medical Drive, MD10, YLLSoM, Singapore 117594
Tel: 6516 3217/3200
Email: antstd@nus.edu.sg
Website: https://nus.edu.sg/lsi/principal-investigators-3/assoc-prof-s-thameem-dheen/

Major Research Interests

  • Role of microglia in memory formation and learning
  • Understanding the role of microglia in cognitive processes in healthy aging brain
  • Molecular and epigenetic mechanisms underlying microglia-mediated neuroinflammation and neuroprotection
  • Unravelling the molecular and epigenetic landscape of maternal diabetes-induced neurodevelopmental disorders

    • Selected Recent Publications

    1.Kandilya D; Shyamasundar S; Singh DK; Banik A; Hande MP; Stünkel W; Chong YS; Dheen ST (2020). High glucose alters the DNA methylation pattern of neurodevelopment associated genes in human neural progenitor cells in vitro. Scientific Reports Vol. 10 (1):15676.
    2. Gupta N; Jadhav S; Tan K-L; Saw G; Mallilankaraman KB; Dheen ST (2020). miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A. Frontiers In Cellular Neuroscience Vol. 14:132.
    3. Saw G; Krishna K; Gupta N; Soong TW; Mallilankaraman K; Sajikumar S; Dheen ST (2019). Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. GLIA Vol. 68 (3), pp. 656 – 669.
    4. Subhramanyam CS; Wang C; Hu Q; Dheen ST (2019). Microglia-mediated neuroinflammation in neurodegenerative diseases. Seminars In Cell & Developmental Biology Vol. 94, pp. 112 – 120.
    5. Kandilya D; Maskomani S; Shyamasundar S; Tambyah PA; Yng CS; Lee RCH; Hande MP; Mallilankaraman K; Chu JTH; Dheen ST (2019). Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells. Epigenomics Vol. 11 (10), pp. 1143 – 1162.
    6. Karthikeyan A; Gupta N; Tang C; Mallilankaraman K; Silambarasan M; Shi M; Lu L; Ang BT; Ling EA; Dheen ST (2018). Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment. Oncotarget Vol. 9 (38) pp. 24950 – 24969.
    7. Patnala R; Arumugam T; Gupta N; Dheen ST (2017). HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke. Molecular Neurobiology Vol. 54 (8), pp. 6391 – 6411.