Assoc Prof Sajikumar Sreedharan

 

Sajikumar Sreedharan
Ph.D
Associate Professor, Department of Physiology
Centre for Life Sciences
National University of Singapore
28 Medical Drive, #05-01, Singapore 117456
Tel: (65)65165886
Email: phssks@nus.edu.sg
Website: http://www.med.nus.edu.sg/phys/lab/Saji_Lab/index.html

Major Research Interests

  • Neural basis of long-term memory (LTM).
  • Synaptic tagging and capture (STC) as an elementary mechanism for storing LTM in neural networks
  • Metaplasticity as a compensatory mechanism for improving memory in neural networks
  • Epigenetic regulation of plasticity and memory
  • Aging and Neurodegeneration

    • Recent Publications

    Please refer to the link for complete publications:
    https://pubmed.ncbi.nlm.nih.gov/?term=sajikumar+s&sort=date
    1. Singh AK, Neo SH, Liwang C, Pang KKL, Leng JCK, Sinha SH, Shetty MS, Vasudevan M, Rao VJ, Joshi I, Eswaramoorthy M, Pavon MV, Sheila AR, Navakkode S, Kundu TK*, Sajikumar S*. (2022) Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons. Aging Cell. 2022. Aug 12:e13675. doi: 10.1111/acel.13675. PMID: 35962576. * Co-corresponding authors
    2. Pavon MV, Navakkode S, Wong LW, Sajikumar S (2022). Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer’s disease. Semin Cell Dev Biol. 2022 Apr 14:S1084-9521(22)00130-6. doi: 10.1016/j.semcdb.2022.04.005. PMID: 35431138.
    3. Chong YS, Wong LW, Gaunt J, Lee YJ, Goh CS, Morris RGM, Ch’ng TH, Sajikumar S (2022). Distinct contributions of ventral CA1/amygdala co-activation to the induction and maintenance of synaptic plasticity. Cerebral Cortex. 2022 Mar 7:bhac093. doi: 10.1093/cercor/bhac093. PMID: 35253866
    4. Krishna-K K, Behnisch T, Sajikumar S (2022). Modulation of the Ubiquitin-Proteasome System Restores Plasticity in Hippocampal Pyramidal Neurons of the APP/PS1 Alzheimer’s Disease-Like Mice. J Alzheimers Dis. 2022;86(4):1611-1616. doi: 10.3233/JAD-215718. PMID: 35253770
    5. Wong LW, Wang Z, Ang SRX, Sajikumar S (2022). Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit? Ageing Res Rev. 2022 Mar;75:101567. doi: 10.1016/j.arr.2022.101567. Epub 2022 Jan 17. PMID: 35051645 Review.
    6. Navakkode S, Gaunt JR, Pavon MV, Bansal VA, Abraham RP, Chong YS, Ch’ng TH, Sajikumar S*. (2021). Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer’s disease. Aging Cell. 2021 Nov 18:e13502. doi: 10.1111/acel.13502. Online ahead of print. PMID: 34796608. * Co-corresponding authors
    7. Benoy A, Bin Ibrahim MZ, Behnisch T, Sajikumar S (2021). Metaplastic Reinforcement of Long-Term Potentiation in Hippocampal Area CA2 by Cholinergic Receptor Activation. Journal of Neuroscience. 2021 Nov 3;41(44):9082-9098. doi: 10.1523/JNEUROSCI.2885-20.2021. Epub 2021 Sep 24. PMID: 34561235
    8. Wong LW, Chong YS, Lin W, Kisiswa L, Sim E, Ibáñez CF, Sajikumar S. Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor. Aging Cell. 2021 Jan 15:e13305. doi: 10.1111/acel.13305.
    9. Krishna-K K, Baby N, Raghuraman R, Navakkode S, Behnisch T, Sajikumar S (2020). Regulation of aberrant proteasome activity re-establishes plasticity and long-term memory in an animal model of Alzheimer’s disease. FASEB J. 2020 May 27. doi: 10.1096/fj.201902844RR.
    10. Dasgupta A, Yu Jia L, Krishna K, Baby N, Pang KKL, Benoy A, Behnisch T and Sajikumar S (2020). Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2. Elife. 2020 Apr 20;9:e55344. doi: 10.7554/eLife.55344.
    11. Wong LW, Tann JY, Ibanez CF, Sajikumar S. The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation. The journal of Neuroscience. 2019 Jul 10;39(28):5452-5465. doi: 10.1523/JNEUROSCI.2876-18.2019. Epub 2019 May 13.
    12. Pang KKL, Sharma M, Krishna-K K, Behnisch T, Sajikumar S.(2019). Long-term population spike-timing-dependent plasticity promotes synaptic tagging but not cross-tagging in rat hippocampal area CA1. PNAS. 2019 Feb 28. pii: 201817643. doi: 10.1073/pnas.1817643116.
    13. Sharma M, Sajikumar S (2018). G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons. Cerebral Cortex. 2018 Jul 6. doi: 10.1093/cercor/bhy161
    14. Luo SX, Huang J, Li Q, Mohammad H, Lee CY, Krishna K, Kok AM, Tan YL, Lim JY, Li H, Yeow LY, Sun J, He M, Grandjean J, Sajikumar S, Han W, Fu Y. (2018). Regulation of feeding by somatostatin neurons in the tuberal nucleus. SCIENCE. 2018 Jul 6;361(6397):76-81. doi: 10.1126/science.aar4983.
    15. Benoy, A., Dasgupta, A., & Sajikumar, S. (2018). Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit. Experimental brain research, 1-13.
    16. Dasgupta, A., Baby, N., Krishna, K., Hakim, M., Wong, Y. P., Behnisch, T& Sajikumar, S. (2017). Substance P induces plasticity and synaptic tagging/capture in rat hippocampal area CA2. PNAS, 114(41), E8741-E8749.
    17. Shetty, M. S., Sharma, M., & Sajikumar, S. (2017). Chelation of hippocampal zinc enhances long‐term potentiation and synaptic tagging/capture in CA1 pyramidal neurons of aged rats: implications to aging and memory. Aging cell, 16(1), 136-148.
    18. Li, Q., Navakkode, S., Rothkegel, M., Soong, T. W., Sajikumar, S., & Korte, M. (2017). Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer’s disease. PNAS, 114(21), 5527-5532.
    19. Shetty, M. S., Sajikumar, S. (2017). Differential involvement of Ca2+/calmodulin-dependent protein kinases and mitogen-activated protein kinases in the dopamine D1/D5 receptor-mediated potentiation in hippocampal CA1 pyramidal neurons. Neurobiology of learning and memory, 138, 111-120.
    20. Sharma, M., Dierkes, T., & Sajikumar, S. (2017). Epigenetic regulation by G9a/GLP complex ameliorates amyloid‐beta 1‐42 induced deficits in long‐term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons. Aging cell, 16(5), 1062-1072.
    21. Sharma M, Razali N & Sajikumar S (2016). Inhibition of G9a/GLP complex promotes long-term potentiation and Synaptic tagging / capture in hippocampal CA1 pyramidal. Cerebral Cortex. 2016 Jun 1. pii: bhw170.
    22. Shetty MS, Sharma M & Sajikumar S (2016). Chelation of Hippocampal Zinc enhances Long-Term Potentiation and synaptic tagging/capture in CA1 Pyramidal Neurons of Aged Rats: Implications to Aging and Memory. Aging Cell, 2016 Sep 16. doi: 10.1111/acel.12537.
    23. Krishna K, Behnisch T, Sajikumar S. (2016). Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons. J Alzheimers Dis. 2016 Feb 10;51(3):783-91. doi: 10.3233/JAD-150838.
    24. Sharma M, Shetty MS, Arumugam TV and Sajikumar S (2015). Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B. Scientific Reports 2015; 5: 16616, doi:10.1038/srep16616