Dr Andrew Tan Yong Yi

 

Andrew Tan Yong Yi
Ph.D.
Assistant Professor
Department of Physiology & Healthy Longevity Translational Research Programme
Yong Loo Lin School of Medicine
Neurobiology Programme, Life Sciences Institute
National University of Singapore
Centre for Life Sciences
28 Medical Drive, #05-01
Singapore 117456
Tel: 6516 955
Email: phstya@nus.edu.sg
Website: https://sites.google.com/site/randomnnetworks
https://nus.edu.sg/lsi/principal-investigators-3/dr-andrew-tan-yong-yi/

Major Research Interests

  • Synaptic mechanisms of complex sound processing in the central auditory system
  • Synaptic mechanisms of adult plasticity in the central auditory system

    • Recent Publications

    1. Kumar MG, Tan C, Libedinsky C, Yen SC, Tan AY. One-shot learning of paired associations by a reservoir computing model with Hebbian plasticity. Preprint at https://arxiv.org/abs/2106.03580, 2021.
    2. Chew KCM, Kumar V, Tan AY. Different excitation-inhibition correlations between spontaneous and tone-evoked activity in primary auditory cortex neurons. Neuroscience 496: 205-218, 2022
    3. Kumar MG, Tan C, Libedinsky C, Yen SC, Tan AY. A nonlinear hidden layer enables actor-critic agents to learn multiple paired association navigation. Cerebral Cortex 32:3917-3936, 2022.
    4. Wang W, Shanmugam MK, Xiang P, Kumar V, Wee SC, Chang JK, Ali MZ, Reolo MJY, XP Yee, Abdul Karim SN, Tan AY, Sanda T, Sethi G, Herr DR. Sphingosine 1-phosphate receptor 2 induces otoprotective responses to cisplatin treatment. Cancers 12: 211, 2020.
    5. Tan AY. Spatial diversity of spontaneous activity in the cortex. Front. Neural Circuits 9:48, 2015.
    6. Tan AY, Chen Y, Scholl B, Seidemann E, Priebe NJ. Sensory stimulation shifts visual cortex from synchronous to asynchronous states. Nature 509:226-229, 2014.
    7. Scholl B, Tan AY, Priebe NJ. Strabismus disrupts binocular synaptic integration in primary visual cortex. J Neurosci 33:17108-17122, 2013.
    8. Scholl B, Tan A, Corey J, Priebe NJ. Emergence of orientation selectivity in the mammalian visual pathway. J Neurosci 33:10616-10624, 2013.
    9. Tan AY, Andoni S, Priebe NJ. A spontaneous state of weakly correlated synaptic excitation and inhibition in visual cortex. Neuroscience 247:364-375, 2013.
    10. Tan AY, Brown BD, Scholl B, Mohanty D, Priebe NJ. Orientation Selectivity of Synaptic Input to Neurons in Mouse and Cat Primary Visual Cortex. J Neurosci 31:12339-12350, 2011.
    11. Wehr M, Hostick U, Kyweriga M, Tan A, Weible AP, Wu H, Wu W, Callaway EM, Kentros C. Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR). J Neurophysiol 102:2554-62, 2009.
    12. Tan AY, Wehr M. Balanced tone-evoked synaptic excitation and inhibition in mouse auditory cortex. Neuroscience 163:1302-1315, 2009.
    13. Tan AY, Atencio CA, Polley DB, Merzenich MM, Schreiner CE. Unbalanced synaptic inhibition can create intensity-tuned auditory cortex neurons. Neuroscience 146:449-462, 2007.
    14. Tan AY, Zhang LI, Merzenich MM, Schreiner CE. Tone-evoked excitatory and inhibitory synaptic conductances of primary auditory cortex neurons. J Neurophysiol 92:630-643, 2004.
    15. Zhang LI, Tan AY, Schreiner CE, Merzenich MM. Topography and synaptic shaping of direction selectivity in primary auditory cortex. Nature 424:201-205, 2003.
    16. Misawa H, Sherr EH, Lee DJ, Chetkovich DM, Tan A, Schreiner CE, Bredt DS. Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice. J Neurosci 22:10088-10093, 2002.
    17. Tan A, Moratalla R, Lyford GL, Worley P, Graybiel AM. The activity-regulated cytoskeletal-associated protein arc is expressed in different striosome-matrix patterns following exposure to amphetamine and cocaine. J Neurochem 74:2074-2078, 2000.