Amaury Cazenave Gassiot
Research Assistant Professor, Department of Biochemistry
Yong Loo Lin School of Medicine
Tel: +65 6516 8174
Email: bchacgt@nus.edu.sg

What are your present research interests?

My main research interest is mass spectrometry-based lipidomics. Our team develops methods for qualitative and quantitative analysis of complex lipid profiles as a readout of biochemical processes.

Do you have a distinctive viewpoint to your research?

The field of mass spectrometry-based lipidomics has now reach a point where translation to clinical applications is around the corner. In this context, we must strive to 1) educate the community as to what lipidomics can and cannot to, 2) develop ever better analytics, and 3) establish widely accepted guidelines for validation and reproducibility.

What do you see as your future research directions?

After working for many years in all types of model organisms, we now work more and more with clinicians, in view of translating our findings into applications of societal and economic value. Meanwhile we will continue to support basic research in lipidomics.

Does your laboratory have a particularly strong research expertise?

We have a strong expertise in targeted quantitative analysis of various classes of lipids (glycerolipids, phosphoglycerolipids, sphingolipids, fatty acids, sterols and derivatives) in a variety of tissues (plants, bacteria, yeast, animal models, and human).

Recent Publications

1. Zonation, ligand and dose dependence of S1PR1 signalling in blood and lymphatic vasculature. I. Del Gaudio, (…), A. Cazenave-Gassiot, Kh. Ben Alaya, P. Thérond, J. Chun, M.R. Wenk, R.L. Proia, D. Henrion, L.N. Nguyen, A. Eichmann, E. Camerer. Cardiovasc. Res. 2024, 14, 1794. doi.org/10.1093/cvr/cvae168. PMID: 39086170 (IF 13.08)
2. Lipidome atlas of the adult human brain. M. Osetrova, A. Tkachev, (…), A. Cazenave-Gassiot, A. Mitina, P. Ogurtsova, S. Guo, D.M. Potashnikova, A.A. Gulin, A.A. Vasin, A. Sarycheva, G. Vladimirov, M. Fedorova, Y. Kostyukevich, E. Nikolaev, M.R. Wenk, E.E. Khrameeva, P. Khaitovich. Nat. Comm. 2024, 15, 4455. doi.org/10.1038/s41467-024-48734-y. PMID: 38796479 (IF 14.7)
3. Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. H.T.T. Ha, (…), J. Oh, M.R. Wenk, A. Cazenave-Gassiot, Z. Yapici, W.-Y. Ong, M. Burmeister, L.N. Nguyen. JCI Insight 2024, 9, e175462. doi.org/10.1172/jci.insight.175462. PMID: 38451736 (IF 9.48)
4. MFSD7c functions as a transporter of choline at the blood-brain barrier. X.T.A. Nguyen, T.N.U. Le, T.Q. Nguyen, H.T.T. Ha, (…), M.R. Wenk, J. Adamski, A. Cazenave-Gassiot, L.N. Nguyen. Cell Res. 2024, 34, 245–257. doi.org/10.1038/s41422-023-00923-y. PMID: 38302740 (IF 46.29)
5. Mfsd7b facilitates choline transport and missense mutations affect choline transport function. H.T.H Ha, V. K. Sukumar, J.W.B. Chua, D.T. Nguyen, T.Q. Nguyen, L.H.K. Lim, A. Cazenave-Gassiot, L.N. Nguyen. Cell. Mol. Life Sci. 2023, 81(1), 3. doi.org/10.1007/s00018-023-05048-4. PMID: 38055060 (IF 9.26)
6. Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ42, phosphorylated α-synuclein, and synaptopathology. J.R. Chong, Y.L. Chai, H. Xing, D.R. Herr, M.R. Wenk, P.T. Francis, C. Ballard, D. Aarsland, D.L. Silver, C.P. Chen, A. Cazenave-Gassiot*, M.K.P. Lai. Brain Pathol. 2023, e13190. doi.org/10.1111/bpa.13190. PMID: 37463072 (IF 5.8)