Xue Bo
Research Assistant Professor
Department of Biochemistry, Yong Loo Lin School of Medicine
Principal Investigator, NUS SynCTI
Tel: +65 6601 2449
Email: bchxbo@nus.edu.sg

What are your present research interests?

I’m interested in structure-guided protein engineering. Current focuses include enzymes for food and energy industries, and scaffold proteins for biotransformation.

Do you have a distinctive viewpoint to your research?

I try to decipher protein structure-function relationships that are not only intellectually stimulating, but also hold great promise for industrial and translational applications.

What do you see as your future research directions?

I hope to be able to achieve rational design of enzymes with high confidence.

Does your laboratory have a particularly strong research expertise?

Aa structural biologist, I specialize in X-ray crystallography, and have active collaborations for cryoEM projects.

Recent Publications

1. Tan YQ*, Ali S*, Xue B*, et al. Assembly and Structural Characterization of Simplified Alpha-Carboxysome Shells. (submitted)
2. Go MK*, Zhao LN*, Xue B*, Supekar S, Robinson RC, Fan H, et al. Directed Computational Evolution of Quorum-Quenching Lactonases from the Amidohydrolase Superfamily. Structure. 2020 Apr 6
3. Sun H, Yeo WL, Lim YH, Chew X, Smith DJ, Xue B, et al. Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate. Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14277–80.
(* co-first authors)