Dr Daniel Teh Boon Loong

 

Daniel Teh Boon Loong
BSc, MSc, PhD (Tohoku)
Assistant Professor, Departments of Ophthalmology, Anatomy and Biomedical Engineering, NUS
Centre for Life Sciences
28 Medical Drive
#05-01, Singapore 117456
Tel: 6772 5311
Email: danielteh@nus.edu.sg
Website: https://discovery.nus.edu.sg/6030-boon-loong-daniel-teh
https://nus.edu.sg/lsi/principal-investigators/dr-daniel-teh-boon-loong/

Major Research Interests

Developing inter-disciplinary technologies for neuroscience application and translational therapeutics.

  • Interdisciplinary wireless optical technologies (optogenetics and Photodynamic therapy).
  • Eye-Brain Health Axis research (Elucidating how age-related pathological conditions in the eye affects the brain and could be used as a window to the brain).
  • Glioblastoma multiforme therapeutics.

    • Recent Publications

    1. Daniel BL Teh* (co-first author), Bansal, A*., Chai, C*., Toh, TB., Tucker, RAJ., Gammad, GGL., Yeo, Y., Lei, Z. Zheng., X. et al. Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Adv. Mater. 2020. https://doi.org/10.1002/adma.202001459
    2. All AH, Zeng X, Teh DBL, Yi Z, Prasad A, Ishizuka T, Thakor N, Hiromu Y, Liu X. Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation. Adv. Mater. 2019 Aug 20:e1803474. doi: 10.1002/adma.201803474.
    3. Liang L, Daniel BL Teh, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor NV, All AH, and Liu X. Upconversion Amplification through Dielectric Superlensing Modulation. Nat. Commun. (2019) 10 (1), 1391. https://doi.org/10.1038/s41467-019-09345-0.
    4. Blasiak A, Guerin THM, Teh DBL, Yang IH, Lahiri A and Thakor NV. Fibro-Neuronal Guidance on Common, 3D-Printed Textured Substrates. T Nanobiosci, (2019). 10.1109/TNB.2019.2905469
    5. Cai X, Bandla A, Chuan CK, Magarajah G, Liao L, Teh DBL, Kennedy BK, Thakor NV and Liu B. Identifying glioblastoma margin using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy. Mater. Horiz., (2018), DOI: 10.1039/C8MH00946E.
    6. Chen S, Adam ZW, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X and McHugh TJ. Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science. (2018); 359, 6376, pp. 679-684. DOI: 10.1126/science.aaq1144
    7. Teh DBL, Chua SM, Prasad A, Kakkos I, Jiang W, Yue M, Liu X, All AH. Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model. Spine J, (2018), 18, 507.
    8. Teh DBL, Prasad A, Jiang W, Ariffin MZ, Khanna S, Belorkar A, Wong L, Liu X and All AH. Transcriptome Analysis Reveals Neuroprotective aspects of Human Reactive Astrocytes induced by Interleukin 1β. Sci Rep. 2017 Oct 25;7(1):13988. doi: 10.1038/s41598-017-13174-w.
    9. Prasad A, Teh DBL, Blasiak, A, Chai C, Wu Y, Gharibani PM, In HY, Thang TP, Lim KL, Yang H, Liu X and All AH. Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors. SciRep, 7, 6743. 2017 Jul 27;7(1):6743. doi: 10.1038/s41598-017-06331-8.
    10. Lee HU, Blasiak A, Agrawal DR, Loong DTB, Thakor NV, All AH, Ho JS and Yang IH. Subcellular electrical stimulation of neurons enhances the myelination of axons by oligodendrocytes. PLoS ONE (2017) 12(7): e0179642. https://doi.org/10.1371/journal.pone.0179642
    11. Prasad A, Teh DB, Shah Jahan FR, Manivannan J, Chua SM and All AH. Direct Conversion Through Trans-Differentiation: Efficacy and Safety. Stem Cells Dev. (2017) 26(3): 154-165. doi:10.1089/scd.2016.0174.
    12. Liang LL, Xie XJ, Daniel TBL, All AH, Huang L and Liu X. Designing Upconversion Nanocrystal Capable of 745 nm Sensitization and 803 nm Emission for Deep-Tissue Imaging. Chem. Eur. J. (2016) DOI: 10.1002/chem.201602514
    13. Prasad A, Manivannan J, Loong DTB, Gharibani PM, All AH. Review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation. Regen. Med. (2016) 11(2), 181-191. DOI 10.2217/rme.16.5
    14. Teh DB, Ishizuka T, Yawo H. Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca2+ channels. Dev Growth Differ. 2014;56(8):583–94. pmid:25283796. (selected for cover image). Differentiation of PZ5 neural stem/progenitor cells.