The NUS Tissue Engineering Programme (NUSTEP) is a multidisciplinary programme that aims to develop core competencies and to create innovations in cell and construct technologies for effective integration of living systems for clinical therapies. The goal is to establish a globally competitive programme in tissue engineering with significant research outcomes that will result in international recognition for high quality research with clinical and industrial applications.
Exploration of ex vivo culture conditions for expansion of mesenchymal stem cells (MSCs) for autologous cell-based cartilage regeneration
Control of MSC chondrogenic differentiation by the manipulation of micro environmental cues
a. Influence of biochemical properties of matrix
b. Influence of surface topography and stiffness
Contribution of physical stimulation to stem cell chondrogenesis
a. Mechanical stimulation
b. Pulsed electromagnetic field (PEMF) stimulation
Study of scaffold microstructural influence on chondrocytes vs MSC chondrogenic differentiation.
Application of label-free biophysically sorted chondrocytes and MSCs in articular cartilage regeneration.
Study of the secretome factors of MSCs and their roles in cartilage tissue regeneration with focus on developing next generation therapies for treatment of articular cartilage injuries and osteoarthritis.
Deciphering the paracrine mechanisms of mesenchymal stem cells (MSCs) in cranio-maxillofacial tissue regeneration with focus on developing next generation therapies for treatment of temporomandibular joint injuries and osteoarthritis.
Investigating the inflammatory response in growth plate injury and the restoration of growth using anti-cytokine approaches.
Tendon and Ligament Tissue Engineering
Bone-Ligament Interface Tissue Engineering
Bone-Cartilage Interface Tissue Engineering
Intraverterbral disc (IVD) Tissue Engineering
Bioreactor/Pulsed Electromagnetic Field for Bone Tissue Engineering
Tissue Engineering approach to the development of an in-vitro 3D tumor model for drug delivery studies
3D Printing for Musculoskeletal Applications
Strategies to decrease bone resorption, wear and infection in implant surgery
Bone regeneration in spinal fusion
Growth factor control release vehicles
Synergiaism between growth factors and stem cells
Visualization of neuropathic pain generators
Pathophysiology of ligamentum flavum hypertrophy
Disc repair and regeneration with novel magnetic hydrogel
3 units of BSL-2 Cleanrooms designated for cell culture work, 2 units certified Class 10K Cleanroom, and the 3rd unit designated for bioreactor-related culture
Bioreactors: Flexcell, compression-shear biaxial stimulator
Low Oxygen tension workstation
Biomaterials and Scaffold Fabrication Laboratory (silk knitting, electrospinning facility)
Surface Modification Laboratory
Bio-Instrument and Microscopy Laboratory
General Research Laboratory allocated to Principal Investigators
Staff and post-graduate student seating areas