Physical therapy is a proven clinical treatment to improve tissue regeneration, but patients with serious spinal injuries are unable to immediately start physical exercises and benefit from them. My goal is to design regenerative biomaterials that provide early interventional mechano-signals.
My team hopes to demonstrate the efficacy of our concept in regeneration rehabilitation in preclinical animals before moving to clinical human trials.
Biomaterials and medical devices for remote field control.
1. Andy Tay, Kunze, A., Murray, C. & Di Carlo, D. Induction of calcium influx in cortical neural networks by nano-magnetic forces (link). ACS Nano (2016).
2. Andy Tay, Schweizer, F. & Di Carlo, D. Micro- and nano-technologies to probe the mechano-biology of the brain (link). Lab on a Chip (2016).
3. Andy Tay, Kunze, A, Jun, D, Hoek, E & Di Carlo, D. The age of cortical neural network affects their interactions with magnetic nanoparticles (link). Small (2016).
4. Andy Tay & Di Carlo, D. Remote control of neuronal activities using magnetic nanoparticles (link). Current Medicinal Chemistry (2016).
5. Andy Tay & Di Carlo, D. Magnetic nanoparticle-based mechanical stimulation for restoration of mechano-sensitive ion channel equilibrium in neuronal networks (link). Nano Letters (2017).
6. Andy Tay, Sohrabi, A., Poole, K., Seidlitis, S. & Di Carlo, D. 3D magnetic hyaluronic acid hydrogels for magneto-mechanical stimulation of primary dorsal root ganglion root neurons (link). Advanced Materials (2018).