Professor Yeoh Khay Guan is Senior Vice President (Health Affairs) at the National University of Singapore (NUS). His concurrent appointments include the Kishore Mahbubani Professor in Medicine and Health Policy and Chief Executive of the National University Health System (NUHS).

Prof Yeoh practises as a Senior Consultant at the Division of Gastroenterology and Hepatology, National University Hospital (NUH). He has served as Dean of NUS Yong Loo Lin School of Medicine from 2011 to 2018.

As Chief Executive of NUHS, he leads an integrated academic health system including public primary care clinics, community, general, and tertiary hospitals, national specialty centers in cancer, cardiovascular, and oral health, and NUS' medical, nursing, dental, and public health schools under one unified governance.

His research interest is in enhancing the early detection of gastric and colorectal cancers. He is the Lead Principal Investigator of the Singapore Gastric Cancer Consortium, a national flagship research group, and chairs the National Colorectal Cancer Screening Committee of the Health Promotion Board, Ministry of Health. He has published more than 200 peer-reviewed papers in international journals, 9 book chapters and has an H-index of 59 with over 11,300 citations. He also serves as a reviewer for several journals and grant funding agencies.

Prof Yeoh received his MBBS (Bachelor of Medicine, Bachelor of Surgery) from NUS in 1987.  He trained in internal medicine and gastroenterology at NUH.  He is a Fellow of the Academy of Medicine, Singapore, Fellow of the Royal College of Physicians of London and Glasgow, and a member of the American Gastroenterology Association and American Society of Gastrointestinal Endoscopy. He has received several awards, including the Nishi-Takahashi Lectureship at the 9th International Gastric Cancer Conference in 2011, the National Medical Excellence Award as Outstanding Clinician Scientist from the Ministry of Health in 2013, and the Public Administration Medal (Gold) in 2022 for his contributions to medical education and healthcare.