Yang Zheng
Senior Research Fellow, NUS Tissue Engineering Program
Life Sciences Institute
Tel: 65165398
Email: lsiyz@nus.edu.sg

What are your present research interests?

My research interest is in the repair of articular cartilage with the use of adult stem cells and primary chondrocytes. The focus is on the investigation and mechanistic understanding of the various microenvironmental cues, and biophysical stimulation, in directing stem cell and chondrocyte cartilage formation.

Do you have a distinctive viewpoint to your research?

For effective cell-based therapy for cartilage regeneration, it is important to understand the complexity of the cartilage tissue, and the biological difference between stem cells and primary chondrocytes, so to provide microenvironment with appropriate biochemical, biophysical and mechanical cue catering to specific cell types for optimise tissue formation.

What do you see as your future research directions?

With collaborative efforts, the aim is to develop novel translational treatment to improve functional cartilage regeneration.

Does your laboratory have a particularly strong research expertise?

Our team consists of research scientists and orthopaedic surgeons in the field of cartilage research and regeneration. We actively collaborate with researchers and engineers with different disciplinary expertise to incorporate novel techniques for the translational application to cartilage repair.

Recent Publications

1. Yang Z*, Wu Y, Neo SH, Yang D, Jeon H, Tee CA, Denslin V, Lin DJ, Lee EH, Boyer LA, Han J*. Size-based microfluidic-enriched mesenchymal stem cell subpopulation enhanced articular cartilage repair. Am J Sports Med. 2024; 52(2):503-515.

2. Yang Y, Wu Y, Yang D, Neo SH, Kadir ND, Goh D, Tan JX, Denslin A, Lee EH, Yang Z*. Secretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles. Bioactive Materials 2023; 27:98-112.

3. Tee CA, Yang Z, Wu Y, Ren X, Maciej BK, Lin DJ , Hassan A, Han J, Lee EH. A pre-clinical animal study for zonal articular cartilage regeneration using stratified implantation of microcarrier expanded zonal chondrocytes. CARTILAGE 2022; 13(2):19476035221093063.

4. Celik C, Franco-Obregón A*, Lee EH, Hui JHP, Yang Z*. Directionalities of magnetic fields and topographic scaffolds synergise to enhance MSC chondrogenesis. Acta Biomaterialia. 2021; 119:169–183.

5. Kadir ND, Yang Z*, Hassan A, Denslin V, Lee EH*. Electrospun fibers enhanced the paracrine signaling of mesenchymal stem cells for cartilage regeneration. Stem Cell Res & Ther. 2021; 12(1):100.

6. Wu Y, Yang Z*, Denslin V, Ren X, Lee CS, Yap FL, Lee EH*. Repair of Osteochondral Defects Using Predifferentiated Mesenchymal Stem Cells of Distinct Phenotypic Character Derived from a Nano-topographic Platform. Am J Sports Med. 2020; 48(7):1735-1747.

7. Yin L, Yang Z, Wu Y, Denslin V, Yu CC, Tee CA, Lim CT, Han J, Lee EH. Label-free separation of mesenchymal stem cell subpopulations with distinct differentiation potencies and paracrine effects. Biomaterials. 2020; 240: 119881.

8. Parate D, Kadir ND, Celik C, Lee EH, Hui JHP, Franco-Obregón A*, Yang Z*. Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration. Stem Cell Res & Ther. 2020; 11(1):46.

9. Tee CA, Yang Z, Yin L, Wu Y, Han J, Lee EH. Improved zonal chondrocyte production protocol integrating size-based inertial spiral microchannel separation and dynamic microcarrier culture for clinical application. Biomaterials. 2019; 220:119409.

10. Yin L, Wu Y, Yang Z, Tee CA, Denslin V, Lai Z, Lim CT, Lee EH, Han J. Microfluidic label-free selection of mesenchymal stem cell subpopulation during culture expansion extends the chondrogenic potential in vitro. Lab Chip. 2018; 18(6):878-889.