Central Library is a multi-disciplinary library serving primarily NUS staff and students from the Faculty of Arts and Social Sciences, the Faculty of Engineering, the School of Computing and the School of Design and Environment. Its special collections include Singapore/Malaysia and Rare Books Collections.

Medicine+Science Library is established in 2023 through the merger of the Medical Library and Science Library. The merger brings together our strong collection on the dentistry, medicine, nursing, pharmacy, biological and life sciences, chemistry, mathematics, statistics & applied probability, materials science and physics.

Wan Boo Sow Chinese Library primarily supports the teaching and research of the Department of Chinese Studies and Department of Japanese Studies. Its collection includes Chinese literature, Chinese history, Chinese philosophy, Chinese linguistics, Chinese Overseas Studies and Japanese materials. It is notable for its strengths in traditional thread-bound Chinese books, Four Treasure Library series, Chinese newspapers published outside China, Taiwan, Hong Kong & Macau, rare Chinese periodicals during the Republic of China, and Southeast Asian Chinese materials.

Music Library is situated on Level 1 of the Yong Siew Toh Conservatory of Music building. Its collection is focused on western art music tradition and comprises books, music scores, CDs, DVDs and journals. A small electronic piano is also in the Library for the convenience of the Conservatory's students and researchers.

Library@BTC houses the Reserve Books and Readings (RBR) Collection for students, staff, and researchers of the Lee Kuan Yew School of Public Policy. It also serves as a collection point for Intra-library Loan items requested from other NUS Libraries.